Premium
Determining jitter values in the very young by use of the e‐norms methodology
Author(s) -
Pitt Matthew C.,
Jabre Joe F.
Publication year - 2017
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25191
Subject(s) - jitter , myasthenia gravis , reference values , interquartile range , cohort , medicine , psychology , statistics , audiology , pediatrics , mathematics , computer science , telecommunications
: The diagnosis of myasthenia gravis in very young infants is a challenging one. In young infants, stimulated single‐fiber electromyography (StimSFEMG) is the most appropriate technique, but it has serious limitations due to the absence of reference values in this subpopulation. Here we present our efforts to derive a reference range of jitter in a patient cohort of infants <3 years of age using the extrapolated norms, or e‐norms, technique. Methods : The e‐norms method was used to calculate jitter mean consecutive difference (MCD) descriptive statistics for children <3 years of age. Results : The e‐norms derived jitter upper MCD limit was 45 μs in children <1 year, 33 μs in those <2 years, and 26 in those <3 years of age. Conclusion : In the absence of jitter reference values for the very young, the e‐norms method can be used as an alternative to derive these values from laboratory cohorts. Muscle Nerve 55 : 51–54, 2017