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Involvement of distal sensory nerves in amyotrophic lateral sclerosis
Author(s) -
Isak Baris,
Tankisi Hatice,
Johnsen Birger,
Pugdahl Kirsten,
Torvin MØLler Anette,
Finnerup Nanna Brix,
Christensen Peter BrØGger,
FuglsangFrederiksen Anders
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25157
Subject(s) - amyotrophic lateral sclerosis , sensory system , orthodromic , medicine , antidromic , sensory nerve , sural nerve , anatomy , neuroscience , psychology , pathology , electrophysiology , disease
The diagnostic criteria for amyotrophic lateral sclerosis (ALS) require normal sensory nerve conduction studies (NCS) or abnormal NCS only in the presence of neuropathy of identified etiology. In this study, we investigated the presence and extent of involvement of Aß sensory fibers in ALS. Methods Distal sensory NCS [antidromic dorsal sural (DS) and orthodromic medial plantar (MP)] and conventional sensory NCS (unilateral median sensory and bilateral sural nerves) were performed in 16 definite and 2 probable ALS patients (based on Awaji criteria) and 31 controls. Results Abnormal conventional sensory NCS were found in 8 (44.4%) ALS patients and 1 (3.2%) control subject ( P = 0.002), whereas abnormal distal sensory NCS were found in 12 (66.7%) ALS patients and 3 (9.6%) controls ( P < 0.0001). Conclusion Distal sensory NCS were more often abnormal than conventional sensory NCS in ALS. Muscle Nerve 54 : 1086–1092, 2016