Isolated gluteal and paravertebral muscle weakness due to anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase antibody–associated necrotizing autoimmune myopathy | Zendy

McGrath Nicole M. | Zendy; Turner Clinton P. | Zendy

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Isolated gluteal and paravertebral muscle weakness due to anti‐3‐hydroxy‐3‐methylglutaryl‐coenzyme a reductase antibody–associated necrotizing autoimmune myopathy

Author(s) -

McGrath Nicole M.,

Turner Clinton P.

Publication year - 2016

Publication title -

muscle and nerve

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.025

H-Index - 145

eISSN - 1097-4598

pISSN - 0148-639X

DOI - 10.1002/mus.25130

Subject(s) - medicine , muscle biopsy , myopathy , weakness , gluteal muscles , mitochondrial myopathy , biopsy , inflammatory myopathy , electromyography , muscle weakness , statin , lumbar , methotrexate , surgery , gastroenterology , endocrinology , biology , biochemistry , psychiatry , mitochondrial dna , gene

: A 56‐year‐old man with a distant history of statin use presented with progressive isolated very proximal lower limb and truncal weakness. Electromyogram (EMG) showed isolated gluteal and lumbar paraspinal muscle involvement. Methods : Gluteus medius muscle biopsy was performed under general anesthesia. Results : The biopsy showed a pauci‐inflammatory necrotizing myopathy. Serum antibodies to 3‐hydroxy‐3‐methylglutaryl‐coenzyme A reductase (HMGCR) were positive. He has since partially responded to corticosteroids and methotrexate. Conclusions : Anti‐HMGCR–associated necrotizing autoimmune myopathy (NAM) can present in a restricted form after cessation of a statin. Biopsy of a symptomatic but uncommonly studied muscle is worthwhile. Muscle Nerve 54 : 150–152, 2016

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