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Macroglossia in advanced amyotrophic lateral sclerosis
Author(s) -
Matsuda Chiharu,
Shimizu Toshio,
Nakayama Yuki,
Haraguchi Michiko,
Hakuta Chiyoko,
Itagaki Yumi,
Ogura Akiko,
Murata Kanako,
Taira Masato,
Numayama Takaya,
Kinoshita Masanobu
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25058
Subject(s) - macroglossia , amyotrophic lateral sclerosis , medicine , body mass index , tongue , logistic regression , disease , pathology
: An enlarged tongue (macroglossia) has been reported in advanced‐stage patients with amyotrophic lateral sclerosis (ALS). Methods : In this study we examined the prevalence of macroglossia and analyzed clinical correlations in 65 ALS patients on tracheostomy‐invasive ventilation (TIV). Results : Macroglossia was found in 22 patients (33.8%). Compared with those without macroglossia, patients with macroglossia had a younger age of onset, longer duration of disease and TIV use, lower ALS Functional Rating Scale score, higher body mass index, lower energy intake, more severe communication impairment, and lower oral function. Logistic multivariate analysis showed that body mass index (BMI; P = 0.007) and communication impairment ( P = 0.029) were significantly correlated with macroglossia. The duration of TIV use was at the cut‐off level of significance ( P = 0.05). Conclusions : Macroglossia may be the result of overfeeding and replacement by fat during long‐term TIV use in patients with advanced ALS. Muscle Nerve , 2016 Muscle Nerve 54 : 386–390, 2016