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Muscle damage, metabolism, and oxidative stress in mdx mice: Impact of aerobic running
Author(s) -
Schill Kevin E.,
Altenberger Alex. R.,
Lowe Jeovanna,
Periasamy Muthu,
Villamena Frederick A.,
RafaelFortney JIll A.,
Devor Steven T.
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.25015
Subject(s) - oxidative stress , duchenne muscular dystrophy , medicine , endocrinology , mdx mouse , myocyte , reactive oxygen species , aerobic exercise , treadmill , vo2 max , skeletal muscle , dystrophin , chemistry , heart rate , biochemistry , blood pressure
We tested how a treadmill exercise program influences oxygen consumption, oxidative stress, and exercise capacity in the mdx mouse, a model of Duchenne muscular dystrophy. Methods: At age 4 weeks mdx mice were subjected to 4 weeks of twice‐weekly treadmill exercise. Sedentary mdx and wild‐type mice served as controls. Oxygen consumption, time to exhaustion, oxidative stress, and myofiber damage were assessed. Results: At age 4 weeks, there was a significant difference in exercise capacity between mdx and wild‐type mice. After exercise, mdx mice had lower basal oxygen consumption and exercise capacity, but similar maximal oxygen consumption. Skeletal muscle from these mice displayed increased oxidative stress. Collagen deposition was higher in exercised versus sedentary mice. Conclusions: Exercised mdx mice exhibit increased oxidative stress, as well as deficits in exercise capacity, baseline oxygen consumption, and increased myofiber fibrosis. Muscle Nerve 54 : 110–117, 2016