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Frequent laboratory abnormalities in CIDP patients
Author(s) -
Abraham Alon,
Albulaihe Hana,
Alabdali Majed,
Qrimli Mohammad,
Breiner Ari,
Barnett Carolina,
Katzberg Hans D.,
Lovblom Leif E.,
Perkins Bruce A.,
Bril Vera
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24978
Subject(s) - medicine , paraproteinemia , chronic inflammatory demyelinating polyneuropathy , anti nuclear antibody , rheumatoid factor , erythrocyte sedimentation rate , gastroenterology , pathology , autoantibody , rheumatoid arthritis , immunology , antibody , multiple myeloma
The role of screening laboratory tests in chronic inflammatory demyelinating polyneuropathy (CIDP) is currently unknown. The objectives of this study are to explore common laboratory test abnormalities in CIDP patients. Methods CIDP subjects attending the Neuromuscular Clinic between 01/2013 and 12/2014 were evaluated. Demographic data, clinical history, physical examination, and laboratory test results were extracted from their charts. Results Seventy‐nine charts were reviewed. Mean age was 61 ± 11 years. Most (84%) CIDP patients had laboratory test abnormalities; the most frequent were paraproteinemia (29%) and elevated HbA1C (28%) and creatine kinase (27%). Additional abnormalities included anemia in 19%, and elevated anti‐neutrophil cytoplasmic antibody, erythrocyte sedimentation rate, and urate in 17%, elevated antinuclear antibodies, rheumatoid factor, and thyroid‐stimulating hormone in 11%, and abnormal C3 in 10%. Conclusions Laboratory test abnormalities were found in most CIDP patients. The most common were paraproteinemia, higher than expected frequency of diabetes, and unexpected CK elevation. Additional abnormalities included anemia, high urate levels, and common biomarkers for vasculitic neuropathies. Muscle Nerve 53 : 862–865, 2016