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The relationship between physical symptoms and health‐related quality of life in oculopharyngeal muscular dystrophy
Author(s) -
Youssof Sarah
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24932
Subject(s) - oculopharyngeal muscular dystrophy , dysphagia , medicine , quality of life (healthcare) , physical therapy , population , weakness , physical medicine and rehabilitation , surgery , environmental health , nursing
Oculopharyngeal muscular dystrophy (OPMD) causes ptosis, dysphagia, and limb weakness. Health‐related quality of life (HRQoL) and its relationship to physical symptoms was investigated. Methods The 36‐item Short Form (SF‐36) was completed by 89 participants in the U.S. OPMD Registry. Multiple hierarchical regression was used to determine the relative contributions of dysphagia severity and lower extremity functional impairment to the physical (PCS) and mental (MCS) components of the SF‐36. Results HRQoL was reduced in OPMD compared with population norms. Lower extremity functional impairment explained a significant proportion of variance in PCS and MCS. Dysphagia symptom severity explained a moderate amount of variance only in MCS. Dysphagia symptom severity had the strongest associations with general health perception and social functioning domains. Conclusions Lower extremity functional impairment in OPMD deserves attention due to its large influence on HRQoL. Both generic and dysphagia‐specific measures are necessary to assess HRQoL in OPMD. Muscle Nerve 53 : 694–699, 2016