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Validation of the besta neurological institute rating scale for myasthenia gravis
Author(s) -
Antozzi Carlo,
Brenna Greta,
Baggi Fulvio,
Camera Giorgia,
Maggi Lorenzo,
Rezzani Cristiana,
Montomoli Cristina,
Mantegazza Renato
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24911
Subject(s) - myasthenia gravis , cronbach's alpha , psychology , rating scale , medicine , physical therapy , psychometrics , clinical psychology , psychiatry , developmental psychology
: We validated the scale for myasthenia gravis (MG) developed at the Neurological Institute Foundation of Milan (INCB‐MG scale). Methods : A total of 174 patients were evaluated with the INCB‐MG and compared with the MG Composite (MGC) as the gold standard. Dimensionality, reliability, and validity of the INCB‐MG scale were studied by principal component factor analysis, Cronbach alpha, and Pearson correlation coefficients; interobserver reliability was calculated by the weighted Cohen K coefficient. Results : Generalized and bulbar INCB‐MG subscales were unidimensional with excellent consistency; the INCB‐MG and MGC scales were strongly correlated. Fatigability assessment was correlated with the INCB‐MG generalized, bulbar, and respiratory subscales. Conclusions : The INCB‐MG scale is a reliable tool to assess MG and is strongly correlated with the MGC. The INCB‐MG scale is a valid tool for every day practice and should be further investigated for its application in clinical trials. Muscle Nerve 53 : 32–37, 2016