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Myotonic dystrophy health index: Correlations with clinical tests and patient function
Author(s) -
Heatwole Chad,
Bode Rita,
Johnson Nicholas E.,
Dekdebrun Jeanne,
Dilek Nuran,
Eichinger Katy,
Hilbert James E.,
Logigian Eric,
Luebbe Elizabeth,
Martens William,
Mcdermott Michael P.,
Pandya Shree,
Puwanant Araya,
Rothrock Nan,
Thornton Charles,
Vickrey Barbara G.,
Victorson David,
Moxley Richard T.
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24725
Subject(s) - myotonic dystrophy , myotonia , medicine , physical therapy , patient reported outcome , cohort , disease , neuromuscular disease , physical medicine and rehabilitation , quality of life (healthcare) , nursing
: The Myotonic Dystrophy Health Index (MDHI) is a disease‐specific patient‐reported outcome measure. Here, we examine the associations between the MDHI and other measures of disease burden in a cohort of individuals with myotonic dystrophy type‐1 (DM1). Methods : We conducted a cross‐sectional study of 70 patients with DM1. We examined the associations between MDHI total and subscale scores and scores from other clinical tests. Participants completed assessments of strength, myotonia, motor and respiratory function, ambulation, and body composition. Participants also provided blood samples, underwent physician evaluations, and completed other patient‐reported outcome measures. Results : MDHI total and subscale scores were strongly associated with muscle strength, myotonia, motor function, and other clinical measures. Conclusions : Patient‐reported health status, as measured by the MDHI, is associated with alternative measures of clinical health. These results support the use of the MDHI as a valid tool to measure disease burden in DM1 patients. Muscle Nerve , 2015 Muscle Nerve 53: 183–190, 2016