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Activity of Krebs cycle enzymes in mdx mice
Author(s) -
Comim Clarissa M.,
Hoepers Andreza,
Ventura Letícia,
Freiberger Viviane,
Dominguini Diogo,
Mina Francielle,
Mendonça Bruna P.,
Scaini Giselli,
Vainzof Mariz,
Streck Emílio L.,
Quevedo João
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24704
Subject(s) - malate dehydrogenase , isocitrate dehydrogenase , succinate dehydrogenase , diaphragm (acoustics) , duchenne muscular dystrophy , endocrinology , citric acid cycle , medicine , mdx mouse , cortex (anatomy) , citrate synthase , biology , dystrophin , enzyme , biochemistry , metabolism , neuroscience , physics , acoustics , loudspeaker
: Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we evaluate Krebs cycle enzymes activity in the cerebral cortex, diaphragm, and quadriceps muscles of mdx mice. Methods : Cortex, diaphragm, and quadriceps tissues from male dystrophic mdx and control mice were used. Results : We observed increased malate dehydrogenase activity in the cortex; increased malate dehydrogenase and succinate dehydrogenase activities in the diaphragm; and increased citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase activities in the quadriceps of mdx mice. Conclusion : This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in mdx mice. Muscle Nerve 53 : 91–95, 2016