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Diurnal and day‐to‐day variation of isometric muscle strength in myasthenia gravis
Author(s) -
Vinge Lotte,
Jakobsen Johannes,
Pedersen Asger Roer,
Andersen Henning
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24696
Subject(s) - isometric exercise , diurnal temperature variation , medicine , myasthenia gravis , muscle strength , ankle , time of day , day to day , physical therapy , surgery , zoology , biology , operations management , atmospheric sciences , economics , geology
In patients with myasthenia gravis (MG), muscle strength is expected to decrease gradually during the day due to physical activities. Methods: Isometric muscle strength at the shoulder, knee, and ankle was determined in 10 MG patients (MGFA class II–IV) who were receiving usual medical treatment and in 10 control subjects. To determine diurnal and day‐to‐day variation, muscle strength was measured 4 times during day 1 and once at day 2. Results: Knee extension strength decreased during the day in both patients and controls. Neither diurnal nor day‐to‐day variation of muscle strength was higher in patients compared with controls. Conclusions: Patients with mild to moderate MG did not have increased variation of isometric muscle strength during the day or from day‐to‐day compared with controls. This suggests that isometric muscle performance can be determined with high reproducibility in similar groups of MG patients without regard to time of day. Muscle Nerve 53 : 67–72, 2016