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The course and outcome of pregnancy in women with nondystrophic myotonias
Author(s) -
Snyder Yuliya,
DonlinSmith Colleen,
Snyder Eric,
Pressman Eva,
Ciafaloni Emma
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24684
Subject(s) - pregnancy , medicine , obstetrics , infertility , fetal distress , distress , fetus , pregnancy rate , gynecology , clinical psychology , genetics , biology
Nondystrophic myotonias (NDM) are muscle channelopathies characterized by clinical and electrical myotonia. Little is known about pregnancy in NDM. The aim of this work was to assess pregnancy outcomes in women with NDM. Methods In this investigation, we utilized a cross‐sectional approach and obtained questionnaire data and medical record review information. Pregnancy outcomes were compared with U.S. national data. Results Twenty‐five women completed the study. There were 63 pregnancies with 53 live births, 8 miscarriages, 4 terminations, and 1 stillbirth. The infertility rate was 28% (above the U.S. average). Fetal distress was reported in 11.7% (U.S. average 3.6%) of the patients. NDM symptoms worsened in 62% of pregnancies. In those who worsened, symptoms usually resolved completely (66%) or partially (32%) after delivery in 2 days to 12 months, the majority (76%) within 3 months. Conclusions Most pregnancy outcomes were favorable. NDM worsened in nearly two‐thirds of pregnancies, but usually improved shortly after delivery. Incidences of infertility and fetal distress were higher than overall U.S. rates. Muscle Nerve 52 : 1013–1015, 2015