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Efficacy and safety of creatine supplementation in juvenile dermatomyositis: A randomized, double‐blind, placebo‐controlled crossover trial
Author(s) -
Solis Marina Yazigi,
Hayashi Ana Paula,
Artioli Guilherme Giannini,
Roschel Hamilton,
Sapienza Marcelo Tatit,
Otaduy Maria Concepción,
De Sã Pinto Ana Lucia,
Silva Clovis Artur,
Sallum Adriana Maluf Elias,
Pereira Rosa Maria R.,
Gualano Bruno
Publication year - 2016
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24681
Subject(s) - medicine , creatine , juvenile dermatomyositis , crossover study , creatine monohydrate , placebo , adverse effect , creatine kinase , dermatomyositis , randomized controlled trial , phosphocreatine , physical therapy , gastroenterology , pathology , alternative medicine , energy metabolism
: It has been suggested that creatine supplementation is safe and effective for treating idiopathic inflammatory myopathies, but no pediatric study has been conducted to date. The objective of this study was to examine the efficacy and safety of creatine supplementation in juvenile dermatomyositis (JDM) patients. Methods : In this study, JDM patients received placebo or creatine supplementation (0.1 g/kg/day) in a randomized, crossover, double‐blind design. Subjects were assessed at baseline and after 12 weeks. The primary outcome was muscle function. Secondary outcomes included body composition, aerobic conditioning, health‐related quality of life, and muscle phosphocreatine (PCr) content. Safety was assessed by laboratory parameters and kidney function measurements. Results : Creatine supplementation did not affect muscle function, intramuscular PCr content, or any other secondary outcome. Kidney function was not affected, and no side effects were reported. Conclusions : Twelve weeks of creatine supplementation in JDM patients were well‐tolerated and free of adverse effects, but treatment did not affect muscle function, intramuscular PCr, or any other parameter. Muscle Nerve 53 : 58–66, 2016