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Neurolymphomatosis: A report of 2 cases representing opposite ends of the clinical spectrum
Author(s) -
Lahoria Rajat,
Dyck P. James B.,
Macon William R.,
Crum Brian A.,
Spinner Robert J.,
Amrami Kimberly K.,
Zeldenrust Steven R.,
Tracy Jennifer A.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24646
Subject(s) - medicine , polyneuropathy , sural nerve , lymphoma , nerve biopsy , pathology , peripheral neuropathy , axonal degeneration , biopsy , presentation (obstetrics) , chronic inflammatory demyelinating polyneuropathy , dermatology , radiology , endocrinology , antibody , immunology , diabetes mellitus
Neurolymphomatosis (NL) is a rare disorder characterized by invasion of cranial or peripheral nerves, nerve roots, or plexi, usually by aggressive subtypes of non‐Hodgkin lymphoma (NHL). The most common clinical presentation is that of a painful polyneuropathy or polyradiculopathy, followed by cranial neuropathy and, less frequently, by painless polyneuropathy. Methods Clinical and pathologic findings are reported for 2 NL cases. Results The following 2 patients with NL, with disparate clinical presentations, are presented: a patient with subacute onset, painful, multifocal, mixed axonal and demyelinating radiculoplexus neuropathy due to a large B‐cell NHL, who required 2 targeted fascicular nerve biopsies to demonstrate NL; and a patient with a slowly progressive, length‐dependent axonal polyneuropathy due to a low‐grade B‐cell lymphoproliferative disorder, as shown on a diagnostic sural nerve biopsy. Conclusions The cases described illustrate the wide clinical spectrum of NL. Muscle Nerve 52:449–454, 2015