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Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders
Author(s) -
Ferry Arnaud,
Benchaouir Rachid,
Joanne Pierre,
Peat Rachel A.,
Mougenot Nathalie,
Agbulut Onnik,
ButlerBrowne Gillian
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24604
Subject(s) - skeletal muscle , medicine , cardiac function curve , hindlimb , mdx mouse , endocrinology , cardiac muscle , fibrosis , cardiology , heart failure , dystrophin
: The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc‐DMD mdx /J) mice on skeletal and cardiac muscle function have not been studied extensively. Methods : We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction−induced injury, and left ventricular function in mdx mice. Results : We found that voluntary wheel running did not worsen the deficit in force‐generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers. Conclusion : These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender. Muscle Nerve 52 : 788–794, 2015