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Properties of the tibialis anterior muscle after treatment with laser therapy and natural latex protein following sciatic nerve crush
Author(s) -
Muniz Kenia Lemos,
Dias Fernando José,
CoutinhoNetto Joaquim,
Calzzani Ricardo Alexandre Junqueira,
Iyomasa Mamie Mizusaki,
Sousa Luiz Gustavo De,
Santos Thais Tedeschi Dos,
Teles Vanessa De Oliveira,
Watanabe IISei,
Fazan Valéria Paula Sassoli,
Issa João Paulo Mardegan
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24602
Subject(s) - sciatic nerve , medicine , crush injury , tibialis anterior muscle , atrophy , muscle atrophy , anatomy , nerve fiber , anesthesia , pathology , surgery , skeletal muscle
: In this study we evaluated the characteristics of the tibialis anterior muscle after sciatic nerve crush and treatment with low‐level laser therapy (LLLT) or the protein from natural latex (P1). Methods : We studied the following 6 groups of male Wistar rats: control (CG); exposed nerve (EG); injured nerve (IG); injured nerve with LLLT (LG); injured nerve with P1 (PG); and injured nerve with P1 and LLLT (LPG). Results : After 4 weeks, muscle morphology showed improvement in the treated groups; after 8 weeks, the treated groups resembled controls, especially the PG. Morphometry revealed muscle fiber atrophy after nerve injury, with time‐dependent recovery. Histochemical analysis revealed increased intermediate fiber area. The PG was more similar to controls with NADH staining, whereas the LPG more closely resembled controls with SDH staining. Conclusion : Treatment using only P1 proved most efficient, revealing a negative interaction between P1 and LLLT. Muscle Nerve 52 : 869–875, 2015