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Activity attenuates skeletal muscle fiber damage after ischemia and reperfusion
Author(s) -
Walters Thomas J.,
Garg Koyal,
Corona Benjamin T.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24581
Subject(s) - skeletal muscle , medicine , contraction (grammar) , ischemia , in vivo , reperfusion injury , muscle contraction , endocrinology , chemistry , anesthesia , biology , microbiology and biotechnology
: In this investigation we aimed to determine whether: (1) physical activity protects rat skeletal muscle from ischemia/reperfusion (I/R) injury; and (2) continued activity after I/R improves the rate of healing. Methods : Rats were divided into sedentary or active (voluntary wheel running) groups. Active rats ran for 4 weeks before I/R or 4 weeks before plus 4 weeks after I/R. Results : Activity before I/R resulted in 73.2% less muscle damage (Evans blue dye inclusion). Sedentary and active rats had a similar decline in neural‐evoked (∼99%) and directly stimulated (∼70%) in vivo muscle torque, and a similar reduction in junctophilin 1. Active rats produced 19% and 15% greater neural‐evoked torque compared with sedentary rats at 14 and 28 days postinjury, respectively, although the rate of recovery appeared similar. Conclusions : Activity protects against long‐term muscle damage, but not short‐term neural injury or excitation‐contraction uncoupling. Continued activity neither accelerates nor hinders the rate of functional recovery. Muscle Nerve 52: 640–648, 2015