Premium
Effect of caffeine on intrinsic mechanical properties of normal and malignant hyperthermia‐susceptible muscle
Author(s) -
Metterlein Thomas,
Hartung Edmund,
Roewer Norbert,
Anetseder Martin
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24580
Subject(s) - caffeine , contraction (grammar) , malignant hyperthermia , muscle contraction , muscle relaxation , relaxation (psychology) , muscle tension , medicine , chemistry , anesthesia , biophysics , biology , physical medicine and rehabilitation
Malignant hyperthermia (MH) is a potentially lethal anesthesic complication. Pathological symptoms develop after exposure to triggering substances. It remains uncertain whether cellular alterations pre‐exist. Mechanical properties of isolated muscle bundles were examined before and after exposure to a triggering substance. Methods With prior written consent, muscle bundles of 12 MH‐susceptible (MHS) and 56 MH‐nonsusceptible (MHN) individuals were examined before and after exposure to incremental doses of caffeine. Mechanical properties (baseline tension, peak tension, time to peak tension, and relaxation time) were measured. Contraction and relaxation derivatives and contraction–relaxation coupling were calculated and analyzed. Results Mechanical properties were not different between the groups before caffeine application. Caffeine increased peak tension in both groups and baseline tension only in MHS muscle bundles; relaxation time/derivative and contraction–relaxation coupling were prolonged. Conclusions Cellular changes seen in MH are not pre‐existing. Exposure to triggering substance impairs relaxation in MHS muscle. Muscle Nerve 52: 580–583, 2015