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Assessment OF aged mdx mice by electrical impedance myography and magnetic resonance imaging
Author(s) -
Wu Jim S.,
Li Jia,
Greenman Robert L.,
Bennett David,
Geisbush Tom,
Rutkove Seward B.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24573
Subject(s) - electrical impedance myography , magnetic resonance imaging , duchenne muscular dystrophy , medicine , dysferlin , muscular dystrophy , gastrocnemius muscle , skeletal muscle , biomedical engineering , anatomy , radiology , vasodilation
Similar to magnetic resonance imaging (MRI), electrical impedance myography (EIM) is dependent on the presence and location of water in muscle to assess neuromuscular diseases. We compared the 2 technologies in mdx mice to better understand their relationship. Methods: EIM and MRI, using T2 relaxation and diffusion‐weighted imaging (DWI), were performed on the gastrocnemius of 10 mdx and 10 wild‐type mice. Muscle function and tissue composition measurements were compared with the EIM and MRI data. Results: EIM reactance and T2 relaxation mapping can discriminate healthy from diseased mice ( P < 0.001 for both), but DWI could not. Both T2 relaxation and EIM reactance also correlated closely with muscle function/composition and with each other. Conclusion: Given the low cost of EIM and the simplicity of application, it may be a valuable alternative to muscle MRI in Duchenne muscular dystrophy, where simple cumulative indices of muscle health are being sought. Muscle Nerve 52: 598–604, 2015