Premium
Resistance strength training exercise in children with spinal muscular atrophy
Author(s) -
Lewelt Aga,
Krosschell Kristin J.,
Stoddard Gregory J.,
Weng Cindy,
Xue Mei,
Marcus Robin L.,
Gappmaier Eduard,
Viollet Louis,
Johnson Barbara A.,
White Andrea T.,
ViazzoTrussell Donata,
Lopes Philippe,
Lane Robert H.,
Carey John C.,
Swoboda Kathryn J.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24568
Subject(s) - sma* , spinal muscular atrophy , medicine , physical medicine and rehabilitation , resistance training , physical therapy , physical strength , strength training , motor function , mathematics , combinatorics
: Preliminary evidence in adults with spinal muscular atrophy (SMA) and in SMA animal models suggests exercise has potential benefits in improving or stabilizing muscle strength and motor function. Methods : We evaluated feasibility, safety, and effects on strength and motor function of a home‐based, supervised progressive resistance strength training exercise program in children with SMA types II and III. Up to 14 bilateral proximal muscles were exercised 3 times weekly for 12 weeks. Results : Nine children with SMA, aged 10.4 ± 3.8 years, completed the resistance training exercise program. Ninety percent of visits occurred per protocol. Training sessions were pain‐free (99.8%), and no study‐related adverse events occurred. Trends in improved strength and motor function were observed. Conclusions : A 12‐week supervised, home‐based, 3‐day/week progressive resistance training exercise program is feasible, safe, and well tolerated in children with SMA. These findings can inform future studies of exercise in SMA. Muscle Nerve 52 : 559–567, 2015