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Amyloid polyneuropathy caused by wild‐type transthyretin
Author(s) -
Lam Lynda,
Margeta Marta,
Layzer Robert
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24563
Subject(s) - transthyretin , polyneuropathy , amyloidosis , medicine , amyloid (mycology) , pathology , cardiomyopathy , amyloid polyneuropathy , nerve biopsy , biopsy , disease , endocrinology , peripheral neuropathy , heart failure , age of onset , diabetes mellitus
Amyloidosis derived from transthyretin (TTR) molecules is typically caused by mutations of the TTR gene. Methods We describe an elderly patient with a severe length‐dependent polyneuropathy that unexpectedly proved to be caused by wild‐type transthyretin amyloidosis. Results The diagnosis was made by muscle biopsy, because no amyloid deposits were found in the biopsied nerve segment. Most cases of wild‐type transthyretin amyloidosis occur in elderly patients with cardiomyopathy, but a few cases of polyneuropathy have been reported. Conclusions This entity is especially noteworthy in light of emerging treatment options for hereditary transthyretin amyloidosis, which are likely to also be beneficial in wild‐type disease. Muscle Nerve 52 : 146–149, 2015