Premium
Effects of microgravity on the mouse triceps brachii muscle
Author(s) -
Ishihara Akihiko,
Nagatomo Fumiko,
Terada Masahiro,
Fujino Hidemi,
Kondo Hiroyo,
Ishioka Noriaki
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24491
Subject(s) - muscle atrophy , anatomy , forelimb , hindlimb , muscle fibre , succinate dehydrogenase , atrophy , spaceflight , chemistry , myofibril , skeletal muscle , biology , medicine , endocrinology , mitochondrion , biochemistry , engineering , aerospace engineering
: In this study we investigated the effects of microgravity on the fiber properties of the mouse triceps brachii, a forelimb muscle that has no antigravity function. Methods : Mice ( n = 7) were exposed to microgravity for 13 days on the space shuttle Atlantis (Space Transportation System‐135). The fiber cross‐sectional area (CSA) and succinate dehydrogenase (SDH) staining intensity of the triceps brachii muscle were compared with those of controls ( n = 7). SDH activity in this muscle was also estimated. Results : Microgravity did not affect the body weight, muscle weight, or fiber CSA, but there was reduced SDH staining intensity of all types of fibers, irrespective of the muscle region ( P < 0.05). Microgravity also reduced muscle SDH activity ( P < 0.05). Conclusions : Short‐term exposure to microgravity induced a decrease in oxidative capacity, but not atrophy, in the triceps brachii muscle of mice. Muscle Nerve 52 : 63–68, 2015