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Idiopathic inflammatory myopathies evaluated by near‐infrared spectroscopy
Author(s) -
Caliandro Pietro,
Mirabella Massimiliano,
Padua Luca,
Simbolotti Chiara,
Fino Chiara De,
Iacovelli Chiara,
Sancricca Cristina,
Rossini Paolo M.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24476
Subject(s) - myoglobin , medicine , dermatomyositis , deoxygenated hemoglobin , polymyositis , hemoglobin , oxygen , chemistry , biochemistry , organic chemistry
In this study we evaluated whether near‐infrared spectroscopy (NIRS) can determine the metabolic patterns of dermatomyositis (DM), polymyositis (PM), and inclusion‐body myositis (IBM). Methods We enrolled 10 consecutive patients affected by DM, 11 by PM, and 9 by IBM, and 3 groups of healthy controls. We measured changes in oxygenated and deoxygenated hemoglobin/myoglobin in the extensor digitorum communis during venous and arterial occlusion testing (VOT) and post‐occlusion hyperemia. Results DM showed lower oxygen consumption ( P = 0.04) during VOT and reduced oxygen supply after VOT ( P = 0.04) compared with controls. IBM patients showed higher oxygen consumption ( P = 0.04) during VOT and higher oxygen supply after VOT ( P = 0.03) than controls. DM patients showed reduced oxidative metabolism compared with IBM ( P = 0.001), and an impaired ability to supply oxygen compared with PM ( P = 0.03) and IBM ( P = 0.001) patients. Conclusions NIRS differentiated samples of DM and IBM patients from controls, but it could not distinguish PM patients from a sample of healthy subjects. Muscle Nerve 51 : 830–837, 2015