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Primary multifocal lymphoma of peripheral nervous system: Case report and review of the literature
Author(s) -
Del Grande Alessandra,
Sabatelli Mario,
Luigetti Marco,
Conte Amelia,
Granata Giuseppe,
Rufini Vittoria,
Del Ciello Annemilia,
Gaudino Simona,
Fernandez Eduardo,
Hohaus Stefan,
Coli Antonella,
Lauriola Libero
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24354
Subject(s) - medicine , mononeuropathy , lymphoma , magnetic resonance imaging , peripheral nervous system , peripheral neuropathy , pathology , radiology , positron emission tomography , primary central nervous system lymphoma , biopsy , peripheral , pathological , central nervous system , endocrinology , diabetes mellitus
ABSTRACT Introduction : Primary lymphomas of peripheral nerves are extremely rare, and only a few cases have been reported. Methods : We describe the clinical, neurophysiological, radiological, and pathological findings in a 61‐year‐old woman affected by primary multifocal lymphoma of the peripheral nervous system without systemic involvement. Results : Fascicular left femoral nerve biopsy was decisive for the diagnosis of diffuse large B‐cell non‐Hodgkin lymphoma. Magnetic resonance imaging, fluorine‐18 fluorodeoxyglucose positron emission tomography computed tomography, and nerve ultrasound contributed to the diagnosis. Conclusions : Primary lymphoma of peripheral nerves (PLPNs) is a rare but potentially treatable condition, which is frequently misdiagnosed. In the literature, there are very few descriptions of PLPNs, most of which are mononeuropathies. The possibility of a neuropathy associated with lymphoma should be considered in patients with poor response to treatment and severe pain symptoms. Muscle Nerve 50: 1016–1022, 2014