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Quantitative muscle ultrasound in Duchenne muscular dystrophy: A comparison of techniques
Author(s) -
Shklyar Irina,
Geisbush Tom R.,
Mijialovic Aleksandar S.,
Pasternak Amy,
Darras Basil T.,
Wu Jim S.,
Rutkove Seward B.,
Zaidman Craig M.
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24296
Subject(s) - duchenne muscular dystrophy , ultrasound , medicine , muscular dystrophy , intraclass correlation , anatomy , radiology , clinical psychology , psychometrics
Muscle pathology in Duchenne muscular dystrophy (DMD) can be quantified using ultrasound by measuring either the amplitudes of sound‐waves scattered back from the tissue [quantitative backscatter analysis (QBA)] or by measuring these backscattered amplitudes after compression into grayscale levels (GSL) obtained from the images. Methods : We measured and compared QBA and GSL from 6 muscles of 25 boys with DMD and 25 healthy subjects, aged 2‐14 years, with age and, in DMD, with function (North Star Ambulatory Assessment). Results : Both QBA and GSL were measured reliably (intraclass correlation ≥ 0.87) and were higher in DMD than controls ( P < 0.0001). In DMD, average QBA and GSL measured from superficial regions of muscle increased (rho ≥ 0.47, P < 0.05) with both higher age and worse function; in contrast, GSL measured from whole regions of muscle did not. Conclusions : QBA and GSL measured from superficial regions of muscle can similarly quantify muscle pathology in DMD. Muscle Nerve 51 : 207–213, 2015