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Negative effect of clenbuterol on physical capacities and neuromuscular control of muscle atrophy in adult rats
Author(s) -
Lang Guillaume,
Dercourt Valerie,
Bisson JeanFrançois
Publication year - 2015
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24273
Subject(s) - clenbuterol , isometric exercise , anabolism , muscle atrophy , muscle mass , medicine , endocrinology , grip strength , myotonia , skeletal muscle , physical therapy , myotonic dystrophy
: Clenbuterol has been used to alleviate chronic obstructive pulmonary disease and elicit an anabolic response in muscles. The aim of this study was to determine the influence of muscle mass variation on physical capacities in rats. Methods : The left hindlimbs of Wistar rats were immobilized for 20 days in plantarflexion with a splint and then remobilized for 16 days. The effect of a non‐myotoxic dose of clenbuterol during the immobilization period was evaluated. Physical capacities were coordination, free locomotion, grip strength, and bilateral deficit. Results : Immobilization induced a loss of muscle mass, coordination, and strength without any effect on free locomotion. The positive anabolic effect of clenbuterol did not prevent a loss of physical capacities resulting from immobilization. Conclusions : Muscle mass correlated strongly with coordination and isometric strength in untreated rats. Anabolic effect, fiber phenotype modification, and perturbation in neuromuscular communication with clenbuterol improved muscle mass, but it altered physical capacities. Muscle Nerve 52 : 1078–1087, 2015