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Muscle–fat MRI: 1.5 tesla and 3.0 tesla versus histology
Author(s) -
Smith Andrew C.,
Parrish Todd B.,
Abbott Rebecca,
Hoggarth Mark A.,
Mendoza Karl,
Chen Yu Fen,
Elliott James M.
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24255
Subject(s) - histology , biopsy , nuclear medicine , muscle biopsy , magnetic resonance imaging , medicine , biomedical engineering , anatomy , pathology , radiology
: We evaluated muscle/fat fraction (MFF) accuracy and reliability measured with an MR imaging technique at 1.5 Tesla (T) and 3.0T scanner strengths, using biopsy as reference. Methods : MRI was performed on muscle samples from pig and rabbit species ( n = 8) at 1.5T and 3.0T. A chemical shift based 2‐point Dixon method was used, collecting in‐phase and out‐of‐phase data for fat/water of muscle samples. Values were compared with MFFs calculated from histology. Results : No significant difference was found between 1.5T and 3.0T ( P values = 0.41–0.96), or between histology and imaging ( P = 0.83) for any muscle tested. Conclusions : Results suggest that a 2‐point Dixon fat/water separation MRI technique may provide reliable quantification of MFFs at varying field strengths across different animal species, and consistency was established with biopsy. The results set a foundation for larger scale investigation of quantifying muscle fat in neuromuscular disorders. Muscle Nerve 50:170–176, 2014