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Risk of fracture in patients with Charcot–Marie–Tooth disease
Author(s) -
Pouwels Sander,
Boer Anthonius,
Leufkens Hubert G.M.,
Weber Wim E.J.,
Cooper Cyrus,
Vries Frank
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24240
Subject(s) - medicine , hazard ratio , confidence interval , bone mineral , retrospective cohort study , cohort study , osteoporotic fracture , disease , cohort , osteoporosis , surgery
: In this study we evaluated fracture risk in patients with Charcot–Marie–Tooth (CMT) disease. Methods : We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (1987–2012). Each patient with CMT disease was matched with up to 6 patients without a history of CMT disease. The outcome measure was fractures. Results : The risk of non‐osteoporotic fracture was statistically significantly increased [adjusted hazard ratio (AHR) 1.47, 95% confidence interval (CI) 1.01–2.14], whereas risk of any and osteoporotic fracture did not reach statistical significance compared with control patients [AHR 1.31 (95% CI 0.98–1.74) and AHR 1.10 (95% CI 0.69–1.74), respectively]. Conclusions : CMT patients have a 1.5‐fold increased risk for non‐osteoporotic fracture. Studies with larger numbers of CMT patients and with additional data on CMT subtype, bone mineral density, and functional status should be performed to confirm a true association between CMT and an increased risk of fracture. Muscle Nerve 50 : 919–924, 2014