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Effect of eccentric versus concentric exercise training on mitochondrial function
Author(s) -
IsnerHorobeti MarieEve,
Rasseneur Laurence,
LonsdorferWolf Evelyne,
Dufour Stéphane Pascal,
Doutreleau Stéphane,
Bouitbir Jamal,
Zoll Joffrey,
Kapchinsky Sophia,
Geny Bernard,
Daussin Frédéric Nicolas,
Burelle Yan,
Richard Ruddy
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24215
Subject(s) - concentric , eccentric , skeletal muscle , citrate synthase , respiration , oxidative phosphorylation , anatomy , medicine , endocrinology , biology , chemistry , biochemistry , mathematics , physics , geometry , quantum mechanics , enzyme
: The effect of eccentric (ECC) versus concentric (CON) training on metabolic properties in skeletal muscle is understood poorly. We determined the responses in oxidative capacity and mitochondrial H 2 O 2 production after eccentric (ECC) versus concentric (CON) training performed at similar mechanical power. Methods : Forty‐eight rats performed 5‐ or 20‐day eccentric (ECC) or concentric (CON) training programs. Mitochondrial respiration, H 2 O 2 production, citrate synthase activity (CS), and skeletal muscle damage were assessed in gastrocnemius (GAS), soleus (SOL) and vastus intermedius (VI) muscles. Results : Maximal mitochondrial respiration improved only after 20 days of concentric (CON) training in GAS and SOL. H 2 O 2 production increased specifically after 20 days of eccentric ECC training in VI. Skeletal muscle damage occurred transiently in VI after 5 days of ECC training. Conclusions : Twenty days of ECC versus CON training performed at similar mechanical power output do not increase skeletal muscle oxidative capacities, but it elevates mitochondrial H 2 O 2 production in VI, presumably linked to transient muscle damage. Muscle Nerve 50 : 803–811, 2014