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Effects of isoflurane anesthesia on F‐waves in the sciatic nerve of the adult rat
Author(s) -
Nowicki Marcin,
Baum Petra,
Kosacka Joanna,
Stockinger Maximilian,
Klöting Nora,
Blüher Matthias,
Bechmann Ingo,
Toyka Klaus V.
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24150
Subject(s) - isoflurane , anesthesia , ketamine , sciatic nerve , xylazine , medicine , stimulation , f wave , nerve conduction velocity
Nerve conduction studies provide insights into the functional consequences of axonal and myelin pathology in peripheral neuropathies. We investigated whether isoflurane inhalation anesthesia alters F‐wave latencies and F‐persistence in the sciatic nerve of adult rats. Methods Ten rats were investigated at 3 different isoflurane concentrations followed by ketamine‐xylazine injection anesthesia. To assess F‐wave latencies, a stimulation paradigm was chosen to minimize H‐reflex masking of F‐waves. Results F‐wave persistence rates were reduced with 3.5% isoflurane concentration at 4 and 10 H z supramaximal stimulation and marginally reduced with 2.5% isoflurane when compared with ketamine‐xylazine. F‐wave amplitudes decreased progressively with rising stimulus frequency in all types of anesthesia and most at 3.5% isoflurane concentration. Conclusions The type of anesthesia and the stimulus repetition rate have an impact on some F‐wave parameters. Higher isoflurane concentrations and repetition rates are not recommended in experimental studies using rat neuropathy models where F‐waves are of interest. Muscle Nerve 50:257–261, 2014