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Electrical impedance myography correlates with standard measures of Als severity
Author(s) -
Rutkove Seward B.,
Caress James B.,
Cartwright Michael S.,
Burns Ted M.,
Warder Judy,
David William S.,
Goyal Namita,
Maragakis Nicholas J.,
Benatar Michael,
Sharma Khema R.,
Narayanaswami Pushpa,
Raynor Elizabeth M.,
Watson Mary Lou,
Shefner Jeremy M.
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24128
Subject(s) - electrical impedance myography , amyotrophic lateral sclerosis , physical medicine and rehabilitation , physical therapy , rating scale , medicine , psychology , disease , developmental psychology , vasodilation
: Electrical impedance myography (EIM) can be used to assess amyotrophic lateral sclerosis (ALS) progression. The relationship between EIM values and standard assessment measures, however, is unknown. Methods : EIM 50 kH z phase data from 60 subjects who participated in a longitudinal natural history study of ALS were correlated with handheld dynamometry (HHD), the ALS Functional Rating Scale‐Revised (ALSFRS‐R) score, and motor unit number estimation (MUNE). Results : Moderate strength correlations between EIM parameters and HHD were observed for both whole‐body and individual upper and lower extremity values. Similarly, moderate strength correlations were observed between EIM and ALSFRS‐R upper and lower extremity subscores, but not total ALSFRS‐R scores. MUNE correlated significantly with single muscle EIM data but not with whole body or upper or lower extremity values. Conclusions : These results support the concept that EIM can serve as a meaningful measure of disease severity in ALS. Muscle Nerve 49 :441–443, 2014