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Pathophysiology of immune‐mediated demyelinating neuropathies—part I: Neuroscience
Author(s) -
Franssen Hessel,
Straver Dirk C.G.
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.24070
Subject(s) - neuroscience , pathophysiology , node of ranvier , axonal degeneration , immune system , medicine , peripheral nervous system , pathology , psychology , central nervous system , immunology , myelin
This first article of this review deals with neuroscientific aspects of immune‐mediated demyelinating neuropathies. It describes the anatomy and physiology of normal myelinated axons, methods of studying peripheral nerve physiology, pathophysiological consequences of demyelination or damage at the node of Ranvier, and the mechanisms that may lead to impaired axonal membrane dysfunction or axonal degeneration. This article (part I) will be followed by a second (part II) dealing with clinical aspects of these neuropathies. Muscle Nerve 48 : 851–864, 2013