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Skeletal health in Duchenne dystrophy: Bone‐size and subcranial dual‐energy X‐ray absorptiometry analyses
Author(s) -
King Wendy M.,
Kissel John T.,
Visy Diane,
Goel Prem K.,
Matkovic Velimir
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23963
Subject(s) - duchenne muscular dystrophy , bone mineral , dual energy x ray absorptiometry , medicine , bone health , bone density , dual energy , osteoporosis
: We performed subcranial and bone‐size–adjusted whole body dual‐energy X‐ray absorptiometry (DXA) to evaluate skeletal health in Duchenne dystrophy (DMD). Methods : Total body bone mineral density (TBBMD)‐for‐age, subcranial, and size‐adjusted DXA analyses were performed on 22 DMD patients (5–17 years) and compared with 267 controls from a database. The skull contribution to total body bone mineral content (TBBMC) and corticosteroid effects were also examined. Results : DMD boys had deficits in TBBMD‐for‐age ( Z = −1.2), which increased with age. The skull's contribution to TBBMC decreased from 45% to 15% with growth. Z ‐scores for subcranial skeleton were significantly lower than TBBMC‐for‐area and TBBMD‐for‐age. Conclusions : Size‐adjusted and subcranial analyses improve evaluation of whole body DXA. DMD boys have low BMD for size not commensurate with total body areal BMD‐for‐age. Bone fragility fractures in DMD may result from both decreased BMD and smaller bones. This information is vital to determine appropriate intervention. Muscle Nerve 49:512–519, 2014