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Platelet‐rich plasma limits the nerve injury caused by 10% dextrose in the rabbit median nerve
Author(s) -
Park GiYoung,
Kwon Dong Rak
Publication year - 2014
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23863
Subject(s) - medicine , median nerve , saline , carpal tunnel syndrome , platelet rich plasma , anesthesia , nerve injury , connective tissue , electrophysiology , motor nerve , platelet , surgery , anatomy , pathology
: We evaluated the effect of platelet‐rich plasma (PRP) injection in a rabbit model of dextrose‐induced median nerve injury. Methods : New Zealand white rabbits ( n = 15) were divided randomly into 3 groups. Three different regimens (group 1: 0.1 ml saline; group 2: 10% dextrose with PRP; group 3: 10% dextrose with saline) were injected within the carpal tunnel. Electrophysiological and histological findings were evaluated 12 weeks after the injection. Results : The mean median motor latency in group 3 was significantly longer than that in groups 1 and 2. The cross‐sectional area of the median nerve and subsynovial connective tissue thickness in group 3 were significantly larger than those in groups 1 and 2. Conclusions : PRP injection may be effective in controlling median nerve injury, as demonstrated by improvement in electrophysiological and histological findings 12 weeks after dextrose injection. Muscle Nerve 49 : 56–60, 2014