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Creatine kinase response to high‐intensity aerobic exercise in adult‐onset muscular dystrophy
Author(s) -
Andersen Søren P.,
Sveen MarieLouise,
Hansen Regitze S.,
Madsen Karen L.,
Hansen Jonas B.,
Madsen Mads,
Vissing John
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23846
Subject(s) - medicine , creatine kinase , muscular dystrophy , facioscapulohumeral muscular dystrophy , heart rate , cardiology , intensity (physics) , exercise intensity , vo2 max , physical exercise , physical therapy , creatine , endocrinology , blood pressure , physics , quantum mechanics
We investigated the effect of high‐intensity exercise on plasma creatine kinase (CK) in patients with muscular dystrophies. Methods Fourteen patients with Becker (BMD), facioscapulohumeral (FSHD), or limb‐girdle type 2 (LGMD2) muscular dystrophy, and 8 healthy subjects performed 5 cycling tests: an incremental max test, and tests at 65%, 75%, 85%, and 95% of maximal oxygen uptake (VO 2max ). Heart rate and oxygen consumption were measured during the tests, and plasma CK was measured before, immediately after, and 24 hours after exercise. Results All subjects were able to perform high‐intensity exercise at the different levels. In patients with LGMD2 and FSHD, CK normalized 24 hours after exercise compared with the pre‐exercise value, whereas those with BMD and healthy controls had elevated CK values 24 hours after exercise. Conclusions The findings suggest that high‐intensity exercise is generally well tolerated in patients with LGMD2 and FSHD, whereas those with BMD may be more prone to exercise‐induced damage. Muscle Nerve 48 : 897–901, 2013