Premium
Motor unit firing pattern of vastus lateralis muscle in type 2 diabetes mellitus patients
Author(s) -
Watanabe Kohei,
Gazzoni Marco,
Holobar Ales,
Miyamoto Toshiaki,
Fukuda Kazuhito,
Merletti Roberto,
Moritani Toshio
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23828
Subject(s) - isometric exercise , electromyography , motor unit , contraction (grammar) , type 2 diabetes mellitus , motor unit recruitment , medicine , cardiology , vastus lateralis muscle , physical medicine and rehabilitation , muscle contraction , diabetes mellitus , anatomy , endocrinology , skeletal muscle
: We investigated the motor unit (MU) firing pattern in type 2 diabetes mellitus (T2DM) patients by means of multichannel surface electromyography (SEMG). Methods : Eight T2DM patients and 8 age‐matched, healthy men performed a ramp‐up contraction to 20% of maximal voluntary contraction (MVC). They also performed a sustained contraction at 10% of MVC during isometric knee extension. Multichannel SEMG signals recorded from the vastus lateralis muscle were decomposed with the convolution kernel compensation technique to extract individual MU firing patterns. Results : During the ramp contraction, the extent of MU firing modulation was significantly attenuated in T2DM. Variability of MU firing rate was significantly higher in T2DM at later periods during the sustained contraction. Conclusions : Our findings suggest that T2DM patients manifest characteristic MU activity patterns due possibly to some degree of neuromuscular impairment affecting the integrity of MU firing modulation. Muscle Nerve 48:806–813, 2013