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Guillain–Barré syndrome during childhood: Particular clinical and electrophysiological features
Author(s) -
Devos David,
Magot Armelle,
PerrierBoeswillwald Julie,
Fayet Guillemette,
LeclairVisonneau Laurene,
Ollivier Yolaine,
Nguyen The Tich Sylvie,
Pereon Yann
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23749
Subject(s) - medicine , guillain barre syndrome , acute motor axonal neuropathy , electrophysiology , pediatrics , polyneuropathy , gait disturbance , anesthesia , physical medicine and rehabilitation
Guillain–Barré syndrome ( GBS ) has some specific characteristics in children. Methods In this study we reviewed the clinical, laboratory, electrophysiological, and prognosis features of the 19 children diagnosed with GBS at Nantes University Hospital from 2000 to 2011. Results Gait disturbance and leg pain were the most frequent presenting symptoms. Electrophysiological examinations revealed significant abnormalities even when performed within the first week after onset. Decreased distal CMAP amplitude was noted in 89% of cases. The pattern indicated an acute inflammatory demyelinating polyneuropathy in 95% of cases and acute motor axonal neuropathy in the remaining 5%. About two‐thirds of the children were treated with intravenous immunoglobulin. After >1 year of follow‐up, 17 patients had complete recovery. Conclusion Gait disorder, leg pain, a high rate of distal conduction block, and a good prognosis are among the main specific features of GBS in childhood. Muscle Nerve , 48: 247–251, 2013