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Optical inhibition of motor nerve and muscle activity in vivo
Author(s) -
Liske Holly,
Towne Chris,
Anikeeva Polina,
Zhao Shengli,
Feng Guoping,
Deisseroth Karl,
Delp Scott
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23696
Subject(s) - optogenetics , hypertonia , motor nerve , in vivo , neuroscience , spastic , motor activity , medicine , muscle contraction , chemistry , anatomy , biology , endocrinology , physical medicine and rehabilitation , cerebral palsy , microbiology and biotechnology
: There is no therapeutic approach that provides precise and rapidly reversible inhibition of motor nerve and muscle activity for treatment of spastic hypertonia. Methods : We used optogenetics to demonstrate precise and rapidly reversible light‐mediated inhibition of motor nerve and muscle activity in vivo in transgenic Thy1::eNpHR2.0 mice. Results : We found optical inhibition of motor nerve and muscle activity to be effective at all muscle force amplitudes and determined that muscle activity can be modulated by changing light pulse duration and light power density. Conclusions : This demonstration of optical inhibition of motor nerves is an important advancement toward novel optogenetics‐based therapies for spastic hypertonia. Muscle Nerve 47: 916–921, 2013