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Sonography of the median nerve in CMT1A, CMT2A, CMTX, and HNPP
Author(s) -
Schreiber Stefanie,
Oldag Andreas,
Kornblum Cornelia,
Kollewe Katja,
Kropf Siegfried,
Schoenfeld Ariel,
Feistner Helmut,
Jakubiczka Sibylle,
Kunz Wolfram S.,
Scherlach Cordula,
Tempelmann Claus,
Mawrin Christian,
Dengler Reinhard,
Schreiber Frank,
Goertler Michael,
Vielhaber Stefan
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23681
Subject(s) - median nerve , forearm , sciatic nerve , medicine , anatomy
Introduction : In this study we compare the ultrasound features in the median nerve in patients with different types of Charcot–Marie–Tooth (CMT) disease and hereditary neuropathies with liability to pressure palsies (HNPP) as a typical entrapment neuropathy. Methods : Median nerve ultrasound and conduction studies were performed in patients with CMT1A ( n = 12), MFN2‐associated CMT2A ( n = 7), CMTX ( n = 5), and HNPP ( n = 5), and in controls ( n = 28). Results : Median nerve cross‐sectional area (CSA) was significantly increased in CMT1A, whereas, in axonal CMT2A, fascicle diameter (FD) was enlarged. CSA correlated with nerve conduction slowing in CMT1A and with axonal loss, as shown by motor and sensory nerve amplitudes in both CMT1A and CMT2A. A relatively low wrist‐to‐forearm‐ratio (WFR <0.8) or a relatively high WFR (>1.8) appeared to be unlikely in MFN2 and Cx32 mutations of CMT2A and CMTX, respectively. Conclusion : Differences in CSA, FD, and WFR of the median nerve can be helpful in defining subtypes of hereditary neuropathies. Muscle Nerve 47:385‐395, 2013