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Screening test for malignant hyperthermia in patients with persistent hyperCKemia: A pilot study
Author(s) -
Johannsen Stephan,
Berberich Christina,
Metterlein Thomas,
Roth Cosima,
Reiners Karlheinz,
Roewer Norbert,
Schuster Frank
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23633
Subject(s) - malignant hyperthermia , microdialysis , medicine , creatine kinase , muscle biopsy , halothane , anesthesia , vastus lateralis muscle , biopsy , dialysis , creatinine , creatine , pathology , gastroenterology , surgery , skeletal muscle , central nervous system
: Persistently elevated serum creatine kinase (CK) is frequently associated with predisposition to malignant hyperthermia (MH). We investigated whether a minimally invasive metabolic test is suitable to diagnose MH susceptibility among patients with hyperCKemia. Methods : Thirty‐nine participants were included: 10 were MH susceptible (MHS); 21 MH were non‐susceptible (MHN); and 8 had MHN with persistent hyperCKemia >500 U/L. Microdialysis probes were inserted into the vastus lateralis muscle, and halothane or caffeine was injected via an attached microtubing catheter. Lactate concentrations in dialysis samples were measured spectrophotometrically. Results : Baseline lactate did not differ between the groups. After local application of halothane or caffeine, a significant lactate increase was detected only in the MHS group. Conclusions : Test results were not influenced by hyperCKemia. To avoid risks and complications of a surgical muscle biopsy this microdialysis test might be a useful screening tool for MH susceptibility among patients with persistent CK elevation. Muscle Nerve 47: 677–681, 2013