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A marginal level of dystrophin partially ameliorates hindlimb muscle passive mechanical properties in dystrophin‐null mice
Author(s) -
Hakim Chady H.,
Duan Dongsheng
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23536
Subject(s) - dystrophin , duchenne muscular dystrophy , hindlimb , muscular dystrophy , skeletal muscle , muscle stiffness , itga7 , strain (injury) , endocrinology , anatomy , medicine , biology , stiffness , materials science , composite material
The goal of this study was to determine whether a minimal level of dystrophin expression improves the passive mechanical properties of skeletal muscle in the murine Duchenne muscular dystrophy model. Methods: We compared the elastic and viscous properties of the extensor digitorum longus muscle (EDL) in mdx3cv and mdx4cv mice at 6, 14, and 20 months of age. Both strains are on the C57Bl/6 background, and both lose the full‐length dystrophin protein. Interestingly, mdx3cv mice express a near full‐length dystrophin at ∽5% of the normal level. Results: We found that the stress–strain profile and the stress relaxation rate of the EDL in mdx3cv mice were partially preserved in all age groups compared with age‐matched mdx4cv mice. Conclusion: Our results suggest that a low level of dystrophin expression may treat muscle stiffness in Duchenne muscular dystrophy. Muscle Nerve, 2012