z-logo
Premium
Polysialic acid expression is not necessary for motor neuron target selectivity
Author(s) -
Robinson Grant A.,
Madison Roger D.
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23526
Subject(s) - polysialic acid , reinnervation , motor neuron , neuroscience , downregulation and upregulation , chemistry , motor nerve , neuron , neural cell adhesion molecule , microbiology and biotechnology , biology , biochemistry , cell , gene , cell adhesion , spinal cord
: Recovery after peripheral nerve lesions depends on guiding axons back to their targets. Polysialic acid upregulation by regrowing axons has been proposed recently as necessary for this target selectivity. Methods : We reexamined this proposition using a cross‐reinnervation model whereby axons from obturator motor neurons that do not upregulate polysialic acid regenerated into the distal femoral nerve. Our aim was to assess their target selectivity between pathways to muscle and skin. Results : After simple cross‐repair, obturator motor neurons showed no pathway preference, but the same repair with a shortened skin pathway resulted in selective targeting of these motor neurons to muscle by a polysialic acid–independent mechanism. Conclusion : The intrinsic molecular differences between motor neuron pools can be overcome by manipulation of their access to different peripheral nerve pathways such that obturator motor neurons preferentially project to a terminal nerve branch to muscle despite not upregulating the expression of polysialic acid. Muscle Nerve 47: 364–371, 2013

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here