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Impact of aging on the progression of neuropathy after liver transplantation in transthyretin Val30Met amyloidosis
Author(s) -
Koike Haruki,
Hashimoto Rina,
Tomita Minoru,
Kawagashira Yuichi,
Iijima Masahiro,
Nakamura Tomohiko,
Watanabe Hirohisa,
Kamei Hideya,
Kiuchi Tetsuya,
Sobue Gen
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23480
Subject(s) - medicine , transthyretin , liver transplantation , amyloidosis , transplantation , polyneuropathy , peripheral neuropathy , sural nerve , neuropathic pain , gastroenterology , surgery , pathology , anesthesia , endocrinology , diabetes mellitus
: Information related to the long‐term follow‐up of neuropathy in patients with familial amyloid polyneuropathy after liver transplantation is still scarce. Methods : We describe the neuropathic features of 3 patients with the transthyretin Val30Met mutation. Each patient underwent liver transplantation at an early stage of neuropathy, as indicated by the absence of motor dysfunction and relative preservation of myelinated fibers in sural nerve biopsy specimens. Results : Although the patient with late‐onset disease (at age 60 years) presented with the least amount of amyloid deposition, he had neuropathic progression after liver transplantation. An older early‐onset (at age 40 years) patient reported a slight exacerbation of both somatic and autonomic neuropathic symptoms 10 years after transplantation. However, the younger early‐onset (at age 28 years) patient did not exhibit characteristics suggestive of neuropathy 7 years after transplantation. Conclusion : Aging may determine the progression of neuropathy after liver transplantation. Muscle Nerve, 2012