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Relationship between cervical cord 1 H‐magnetic resonance spectroscopy and clinoco‐electromyographic profile in amyotrophic lateral sclerosis
Author(s) -
Ikeda Ken,
Murata Kiyoko,
Kawase Yuji,
Kawabe Kiyokazu,
Kano Osamu,
Yoshii Yasuhiro,
Takazawa Takanori,
Hirayama Takehisa,
Iwasaki Yasuo
Publication year - 2013
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23467
Subject(s) - amyotrophic lateral sclerosis , medicine , denervation , creatine , phosphocreatine , dyssynergia , spinal cord , in vivo magnetic resonance spectroscopy , bulbar palsy , lower motor neuron , anterior horn cell , magnetic resonance imaging , surgery , disease , urinary system , psychiatry , radiology , energy metabolism
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motor neurons, leading to limb paralysis and respiratory failure. Methods: C1–C3 cord 1 H‐magnetic resonance spectroscopy ( 1 H‐MRS) was performed in 19 patients with ALS and 20 controls. N‐acetylaspartate (NAA), choline‐containing compounds, creatine plus phosphocreatine (Cr), and myo‐Inositol (m‐Ins) were measured. ALS Functional Rating Scale‐Revised (ALSFRS) and forced vital capacity (FVC) were assessed. The rates of decline were calculated at 6 months before and after 1 H‐MRS. Results: NAA/Cr and NAA/m‐Ins were decreased significantly, and m‐Ins/Cr was increased significantly in ALS patients compared with controls. NAA/Cr and NAA/m‐Ins were correlated with ALSFRS and FVC and inversely linked to the decline rates. NAA/Cr, NAA/m‐Ins, and m‐Ins/Cr were altered markedly in 9 patients with denervation and neurogenic changes in both C2 paraspinal and upper limb muscles. Conclusions: These metabolite ratios were associated with disease progression and ongoing denervation in neck and hand muscles. C1–C3 cord 1 H‐MRS might reflect anterior horn cell damage causing neck/arm weakness and respiratory dysfunction in ALS patients. Muscle Nerve, 2013