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Isolated necrotizing myopathy associated with ANTI‐PL12 antibody
Author(s) -
Mehndiratta Prachi,
Mehta Sonal,
Manjila Sunil V.,
Kammer Gary M.,
Cohen Mark L.,
Preston David C.
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23383
Subject(s) - myositis , autoantibody , medicine , muscle biopsy , dermatomyositis , myopathy , connective tissue disease , inflammatory myopathy , connective tissue , ctd , pathology , rash , antibody , immunology , biopsy , autoimmune disease , dermatology , oceanography , geology
Immune‐mediated myopathies are a heterogeneous group of chronic autoimmune disorders. Autoantibodies associated with this disease complex are classified into myositis‐associated and myositis‐specific. Anti‐tRNA synthetase antibodies are the most well known of the myositis‐specific antibodies. Previous reports have revealed an association of tRNA synthetase autoantibodies with systemic connective tissue disorders. Methods: Our case report involved a 49‐year‐old man who developed difficulty walking and climbing stairs 5 months prior to his initial visit. No rash or skin changes were observed. Results: Laboratory testing was positive for anti‐PL12 autoantibody with a negative evaluation for connective tissue disorder (CTD). The patient was found to have necrotizing myopathy associated with anti‐PL12 antibodies in the absence of inflammatory changes on biopsy, significant derangement of muscle enzymes, or findings characteristic of a typical CTD. Conclusion: A high index of suspicion must be maintained for immune‐mediated necrotizing myopathy despite the absence of an identifiable CTD and milder symptoms. Muscle Nerve 46: 282–286, 2012