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Mitochondria of trained skeletal muscle are protected from deleterious effects of statins
Author(s) -
Bouitbir Jamal,
Daussin Frédéric,
Charles AnneLaure,
Rasseneur Laurence,
Dufour Stéphane,
Richard Ruddy,
Piquard François,
Geny Bernard,
Zoll Joffrey
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23309
Subject(s) - skeletal muscle , atorvastatin , mitochondrion , medicine , endocrinology , antioxidant , statin , glycolysis , chemistry , biology , biochemistry , metabolism
: Statins are associated with adverse skeletal muscle effects. Our objective was to determine if muscular adaptations following exercise training prevented deleterious effects of atorvastatin in glycolytic skeletal muscle. Methods : Twenty rats were divided into 2 groups: a control group ( n = 10; Cont) and a 10 days of training group ( n = 10; Training). Using the permeabilized fibers technique, we explored mitochondrial function. Results : Exercise training increased V max and H 2 O 2 production without altering the free radical leak, and mRNA expression of SOD2 and Cox1 were higher in trained muscle. In the Cont group, atorvastatin exposure increased H 2 O 2 production and decreased skeletal muscle V max . The decreased V max effect of atorvastatin was dose dependent. Interestingly, the half‐maximal inhibitory concentration (IC 50 ) was higher in the Training group. H 2 O 2 production increased in trained muscle after atorvastatin exposure. Conclusions : These results suggest that improvements in mitochondrial respiratory and antioxidant capacities following endurance training protected mitochondria against statin exposure. Muscle Nerve 46: 367–373, 2012