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Myasthenia gravis: Sleep quality, quality of life, and disease severity
Author(s) -
MartínezLapiscina Elena Hernández,
Erro María Elena,
Ayuso Teresa,
Jericó Ivonne
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23296
Subject(s) - pittsburgh sleep quality index , epworth sleepiness scale , myasthenia gravis , odds ratio , medicine , quality of life (healthcare) , confidence interval , sleep disorder , disease , physical therapy , sleep (system call) , sleep quality , polysomnography , psychiatry , insomnia , apnea , nursing , operating system , computer science
: There is much research on quality of life in myasthenia gravis (MG), and its relationship to disease severity is well‐established. However, evidence regarding sleep disturbance in MG is inconclusive. Methods : To evaluate sleep and quality of life among clinically stable MG patients, 54 subjects were investigated by means of the Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS) and 15‐Item‐Quality‐Of‐Life Instrument for MG (MG‐QOL15). Results : A pathological PSQI score, which was observed in 59% of patients, was increased in subjects with active disease compared with patients in clinical remission [odds ratio = 4.3; confidence interval 95% (1.0–17.6); P = 0.04]. We found a relationship between PSQI and MG‐QOL15 scores in patients with clinically active disease (r = 0.62; P < 0.001). Conclusions : Our study highlights the high prevalence of sleep disturbance among MG patients. Disease severity may be considered to be a MG‐specific risk factor for patient‐reported sleep disturbance. The MG‐QOL15 and PSQI should be used to estimate the impact of the disease on sleep and quality of life. Muscle Nerve 46: 174–180, 2012