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GDNF released from microspheres enhances nerve regeneration after delayed repair
Author(s) -
Wood Matthew D.,
Kim Howard,
Bilbily Alex,
Kemp Stephen W.P.,
Lafontaine Christine,
Gordon Tessa,
Shoichet Molly S.,
Borschel Gregory H.
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23295
Subject(s) - microsphere , regeneration (biology) , glial cell line derived neurotrophic factor , medicine , neurotrophic factors , microbiology and biotechnology , biology , receptor , chemical engineering , engineering
: Delays in surgical repair following nerve transection produce progressively inferior motor nerve regeneration. Regeneration can be improved with delivery of exogenous growth factor. We developed a delivery system that could be applied at the nerve repair site to deliver growth factors locally to regenerating nerve. Methods : Poly(lactic‐co‐glycolic acid) microspheres containing glial‐derived neurotrophic factor (GDNF) suspended within fibrin were developed into a delivery system for local application surrounding nerve at a repair site in an experimental rat model. Results : The system containing GDNF remained at the injury site for up to 2 weeks and improved motor nerve regeneration following chronic axotomy and denervation. Conclusions : Based on the positive outcome of the delivery system, we plan to study the delivery system over longer time courses of release and nerve regeneration. Muscle Nerve 46: 122–124, 2012
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