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Experimental muscle injury: Correlation between ultrasound and histological findings
Author(s) -
JimÉnezDíaz Fernando,
Jimena Ignacio,
Luque Evelio,
MendizÁbal Susana,
Bouffard Antonio,
JimÉnezReina Luis,
PeÑa JosÉ
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23243
Subject(s) - echogenicity , ultrasound , medicine , anatomy , skeletal muscle , regeneration (biology) , pathology , gastrocnemius muscle , biology , radiology , microbiology and biotechnology
In this study we correlated ultrasound findings with histological changes taking place during experimentally induced degeneration–regeneration in rat skeletal muscle. Methods: Gastrocnemius muscles were injected with mepivacaine, and the progress of the muscle injury was monitored by ultrasound from day 1 to day 20. Muscles were extracted on the same days for histological examination. Results: The degenerative phase was characterized by increased echogenicity in the injured area; thereafter, echogenicity gradually diminished during the regenerative phase, attaining normal levels by 20 days postinjection. By this stage, histological examination revealed that regeneration was complete. The heteroechoic texture observed from day 4 to day 10 appeared to reflect the coexistence of degenerative and regenerative processes. Conclusions: The results suggest that the degenerative and regenerative phases of muscle injury may be distinguished sonographically through differences in echogenicity and echotexture and, using Doppler ultrasound, differences in the degree of vascularization. Muscle Nerve, 2012

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