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Electrical impedance myography in spinal muscular atrophy: A longitudinal study
Author(s) -
Rutkove Seward B.,
Gregas Matt C.,
Darras Basil T.
Publication year - 2012
Publication title -
muscle and nerve
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.025
H-Index - 145
eISSN - 1097-4598
pISSN - 0148-639X
DOI - 10.1002/mus.23233
Subject(s) - electrical impedance myography , sma* , spinal muscular atrophy , medicine , muscle atrophy , physical medicine and rehabilitation , isometric exercise , atrophy , physical therapy , cardiology , disease , mathematics , combinatorics , vasodilation
New approaches for assessing disease progression in spinal muscular atrophy (SMA) are needed. In this study, we evaluate whether electrical impedance myography (EIM) can detect disease progression in SMA compared with a group of healthy children of similar age. Methods: Twenty‐eight children with SMA and 20 normal children underwent repeated EIM testing in four muscles at regular intervals for up to 3 years. An average rate of change of EIM was calculated for each subject and normalized to subcutaneous fat thickness and muscle girth. Results: Multiple EIM parameters showed a change in normal subjects over a mean of 16.7 months; however, no change was found in SMA patients over this period. Conclusions: EIM could detect non–mass‐dependent muscle maturation in healthy children. In contrast, the muscle in children with SMA, as measured by EIM, was virtually static, showing no evidence of growth or active deterioration. Muscle Nerve, 2012